Director, Centre for Research in Mass Spectrometry
Centre for Research in Mass Spectrometry
Office: 331C Life Sciences Building (LSB)
Phone: (416)736-2100 ext. 20786
Lab: 335 Life Sciences Building (LSB)
Graduate Program Appointment
Full Member: Eligible to supervise M.Sc. or Ph.D.
Protein dynamics, structure, and function, including folding; Enzymes; Microfluidics; Time-resolved mass spectrometry; Biophysical Nuclear Magnetic Resonance spectroscopy.
I am interested in protein biophysics, especially dynamics and folding. The tools of structural biology provide beautifully detailed snapshots of the lowest energy (or most readily crystallizable) protein conformation, but offer precious little in the way of dynamic information. Since many aspects of protein function (i.e., substrate binding/release, conformational changes, energy dissipation through bond vibrations, etc.) are inherently dynamic, we are working towards a detailed understanding of the dynamical modes available to proteins that are required to accurately predict their functional characteristics. We use a wide variety of techniques (e.g., microfluidics, time-resolved mass spectrometry, and Nuclear Magnetic Resonance spectroscopy) to facilitate studies of protein conformational dynamics on biologically important millisecond timescales and to characterize the dynamics underlying activity in a number of enzyme systems.